Sucrase is an enzyme produced in the brush border lining of the small intestine and is responsible for the metabolism of sucrose, a disaccharide commonly known as table sugar, into two component monosaccharides, glucose and fructose, which are then absorbed into the circulation
In the absence of the sucrase enzyme, sucrose cannot be absorbed and passes unchanged into the large intestine
Currently, treatment of CSID consists of lifelong adherence to a sucrose-free diet. As expected, compliance is difficult, especially for a child. Data suggest that even after diagnosis and dietary treatment, major gastrointestinal symptoms persist, and there appears to be a high frequency of decreased weight for height and age in these patients
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